At about 1400, a major fire broke out at Dorset Council’s waste management depot in Chickerell, Weymouth, today. At this stage, it's not known how bad the damage is, although many firefighters were sent to the scene. In other news, the PM is self-isolating tonight after coming into contact with a Conservative MP who had tested positive for coronavirus. This came after Mr Johnson had had a 30 minute meeting with my colleague Lee Anderson. Mr Johnson said that he has no symptoms, but is following the rules, and would be leading the government's pandemic response from home. In EU news, the UK's chief Brexit negotiator, Lord Frost, travelled to Brussels today for more trade talks, warning that the process may not succeed. He tweeted that there had been some progress in a positive direction in recent days, but that people and businesses must prepare for the change that is coming on 31 December. Meanwhile, one of the scientists behind the first Covid vaccine to emerge from early clinical trials with high levels of success, says it won't start to make a significant difference until next summer. Professor Ugur Sahin, Chief Executive of BioNTech, said that normal life should be resuming this time next year if mass vaccination programmes had taken place by then. Another 24,962 new infections were recorded in the latest 24-hour period, which means an average of 25,329 new cases per day in the last week, and another 168 deaths were reported today, which brings the total number of UK deaths to 51,934. Finally, The Prince of Wales and the Duchess of Cornwall have become the first members of the royal family to attend Germany's annual commemoration for victims of war and dictatorship.